All businesses in New York State must register with Dutchess County Clerk and get the proper licensing.  New York State provides information to new businesses at their web site:

If you are starting an new Limited Liability Company (LLC), you must contact and register with New York State.

If you are starting a new business or relocating an existing business in East Fishkill, contact the East Fishkill Building Department to see what, if any, Permits you may need.  Call them at (845) 221-2427.